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KMID : 0363320150360020180
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Journal of Korean Oriental Internal Medicine
2015 Volume.36 No. 2 p.180 ~ p.188
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Effects of Paljeong-san (八正散, Bazheng-san) on Chronic Nonbacterial Prostatitis Induced in Rats by Estradiol
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Lee Seung-Wook
Na Hyun-Young
Yoo Jung-Hwa
Ahn Young-Min
Ahn Se-Young
Kim Young-Ock
Lee Byung-Cheol
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Abstract
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Objectives: This study investigated the effects of Paljeong-san on chronic nonbacterial prostatitis induced in rats by estradiol.
Methods: Rats were divided into three groups. The normal group included rats with no intervention after sham castration. The control group included rats with prostatitis induced by 17β-estradiol after orchiectomy; these rats were orally administered normal saline. The sample group rats were administered Paljeong-san after prostatitis induction. Evaluations included changes in epithelial score, body weight, and prostate weight and volume, as well as histopathological changes in prostate tissue and gene expression of TNF-α, COX-2, and CD68.
Results: Paljeong-san inhibited histopathological changes and monocyte/macrophage infiltration of the prostate. The epithelial score was higher for the sample group than for the control group (P<0.05). Paljeong-san administration decreased the gene expression of TNF-α and CD68. Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression.
Conclusions: Paljeong-san shows prostate-protective effects by inhibiting infiltration by monocytes/macrophages and by reducing TNF-α gene expression.
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KEYWORD
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Paljeong-san, prostatitis, inflammation, estradiol
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